Pharmacology of GPCRs

rent-a-lab offers assays for functional-screening of G protein-coupled receptors (GPCRs):

  • [35S]-GTPγS-binding
    for the measurement of G protein activation (for inhibitory and stimulatory G proteins)

    capacity:
    1,500 data points/day
  • adenylate cyclase activity
    for the investigation of stimulated cAMP production

    method:
    Radiotracer method with separation of product ([32P]cAMP) from educt ([32P]ATP) via column chromatography

    capacity:
    300 data points/day